5 Ways Your Body Might React While Taking Prednisone

Synthetic corticosteroids like prednisone are frequently recommended to treat a variety of inflammatory diseases and ailments, such as lupus, rheumatoid arthritis, asthma, and a condition called inflammatory bowel disease. Prednisone can cause a variety of physiological reactions and adverse effects in addition to successfully reducing symptoms and improving the quality of life for many people. It’s critical to comprehend how your body may respond to prednisone in order to manage your therapy and reduce the risk of problems.

Increased Appetite and Weight Gain

Increased hunger is one of the most frequent adverse effects of prednisone, which frequently results in weight gain. Prednisone can increase hunger and desire for high-calorie foods by stimulating hormones that control appetite and changing how proteins, lipids, and carbs are metabolized. Because of this, people could eat more calories than they burn, which could eventually cause them to gain weight gradually. Developing techniques like portion management, mindful eating, and integrating regular physical exercise into daily routines may be necessary to manage hunger and weight while on prednisone. It’s critical to understand that gaining weight while taking prednisone can have effects on mental and emotional health in addition to physical health, calling for a comprehensive approach to support and management.

Fluid Retention and Swelling

Prednisone may result in fluid accumulation and salt retention, which can produce symptoms including edema, swelling, and bloating in the body. Abdominal distension and facial, hand, or foot puffiness are signs of excessive fluid retention. While moderate fluid retention is frequently temporary and goes away on its own, excessive or persistent fluid accumulation might point to the need for medical attention. Reducing salt intake, keeping an active lifestyle, and keeping an eye on fluid intake can all help minimize swelling-related pain and fluid retention. If you have significant or ongoing swelling, it’s best to speak with a healthcare provider since this might be a sign of an underlying medical condition that needs to be further assessed and treated.

Mood Swings and Emotional Changes

Prednisone may cause mood swings, irritation, anxiety, or sadness due to its effects on mood and emotional health. These psychological impacts might be caused by immediate impacts on brain function, changes in hormone release, or changes in neurotransmitter levels. When using prednisone, people may have altered sleep habits, trouble concentrating, or increased emotional sensitivity. Throughout prednisone therapy, mood swings and emotional shifts can be managed by using stress-reduction strategies, keeping up a positive social network, and getting professional counseling or therapy. Any shifts in mood or mental health should be discussed honestly with healthcare professionals, who may offer advice and assistance on how to deal with these issues.

A Higher Chance of Infections

Prednisone increases a person’s susceptibility to infections by reducing the inflammatory response of the immune system. The management of inflammatory disorders benefits from this immunosuppressive effect, but it also raises the risk of infections involving bacteria, viruses, and fungi. Urinary tract infections, oral thrush, and upper infections of the respiratory tract are common illnesses linked to prednisone usage. While on prednisone medication, the risk of infections can be decreased by following prescribed immunization schedules, maintaining excellent cleanliness, and avoiding close contact with ill people. It’s critical to keep an eye out for infection-related symptoms, such as fever, coughing, or strange discharge, and to get medical help right away if you suspect anything.

Bone Loss and Osteoporosis

Osteoporosis risk and rapid bone loss can result from long-term prednisone usage. Prednisone causes reduced bone density or structural fragility by interfering with the absorption of calcium and inhibiting the production of new bone. Osteoporosis can cause bone discomfort, fractures, and height reduction in certain people. For patients on long-term prednisone therapy, healthcare professionals may suggest supplements to take while on prednisone, for example, vitamin D and calcium supplements, frequent lifting weights, and bone density screening as ways to reduce the risk of issues linked to the bones. To reduce the risk of fractures linked to osteoporosis and preserve overall skeletal integrity, prednisone users must emphasize bone health through dietary changes and proper supplements.


Prednisone can be used to treat inflammatory diseases, but it can also cause a number of physiological reactions and adverse effects that might affect a person’s general health. People may maximize treatment success and reduce potential risks by learning how their body can behave while taking prednisone and putting proper management and preventative methods into practice. Maintaining a healthy state of life while managing the difficulties of prednisone medication requires proactive self-care practices, adherence to treatment guidelines, and open dialogue with healthcare practitioners.